Rapid human melanoma cell death induced by sanguinarine through oxidative stress
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چکیده
منابع مشابه
Rapid human melanoma cell death induced by sanguinarine through oxidative stress.
Sanguinarine is a natural isoquinoline alkaloid derived from the root of Sanguinaria canadensis and from other poppy fumaria species, and is known to have a broad spectrum of pharmacological properties. Here we have found that sanguinarine, at low micromolar concentrations, showed a remarkably rapid killing activity against human melanoma cells. Time-lapse videomicroscopy showed rapid morpholog...
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Polymorphonuclear leukocytes (PMN) play crucial roles in protecting hosts against invading microbes and in the pathogenesis of inflammatory tissue injury. Although PMN migrate into mucosal layers of digestive and respiratory tracts, only limited information is available of their fate and function in situ. We previously reported that, unlike circulating PMN (CPMN), PMN in the oral cavity spontan...
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BACKGROUND Embryonic rhabdomyosarcoma (RD) is the most prevalent type of cancer among children. The present study aimed to investigate cell death induced by mangiferin in RD cells. METHODS The Inhibitory concentration (IC50) value of mangiferin was determined by an MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay. Cell death induced by mangiferin against RD cells was d...
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Laboratory of Veterinary Pharmacology, Laboratory of Protein Sciences, Graduate School of Science, Graduate School of Life and Environmental Sciences, Department of Science, Osaka Prefecture University, Izumisano 5988531, Osaka, Japan Phone: +81-72-463-5274, Fax: +81-72463-5264, Development Research Laboratories, Ono Pharmaceutical Co., Ltd., Mishima-gun 6188585, Osaka, Japan, Phone: +81-75-961...
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Notch1 genes encode receptors for a signaling pathway that regulates various aspects of cell growth and differentiation; however, the role of Notch1 signaling in p38 mitogen-activated protein kinase (MAPK) signaling pathway is still not well defined. In this study, we found that Notch1 intracellular domain (Notch1-IC) prevents oxidative stress-induced cell death through the suppression of the A...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2013
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2013.02.035